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Adverse Drug Event Phenotype Ontology (ADEPHONT) Project

Proposal Description

  • This CTSA supplement seeks to leverage existing resources and experience in terminology resources and high-throughput phenotyping to develop and evaluate clinical phenotypes from EHRs (Electronic Health Records) relevant to symptoms and findings associated with Adverse Drug Events (ADEs). The scope of these phenotypes will focus upon “common” phenotypes that by and large are not specific to readily identifiable drugs, but rather focus upon symptoms and findings that are observed for many drug agents. The ultimate goal is to establish a library of EMR algorithms that can identify patients with these symptoms, who may have had specific drug exposures. The potential to establish whether genomic characteristics modulate the frequency or intensity of these manifestations could be explored using these modular phenotypes.
    • 1. To work with the CTSA and pharmacogenomcis communities to identify high-utility phenotypes as potential modules.
    • 2. To develop EMR algorithms that permit good sensitivity and specificity for these phenotypes commonly associated with drug exposures.
    • 3. To evaluate the generalizability of these algorithms at different Mayo settings, and support their evaluation at CTSA sites who are willing to collaborate.

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